Cardiovascular disease - the challenge for biotechnology

• Authors: T. Pietrucha , J. Szemraj
• Languages of publication: PL

Abstracts

EN

The significance of thromboembolic complications in the etiology and development of cardiovascular diseases, such as ischaemic heart disease or myocardial infarction, is undisputable and well documented. It is commonly believed that intravascular thrombi may cause vessel narrowing and even lead to complete vessel occulsion. When encountering circulation, narrowing of vascular lumen, such as intravascular clots and platelet aggregates, is believed to result in thromboembolisms. Activation of the fibrinolytic system allows for the proteolysis of fibrin clots, the main components of vascular thrombi, and thus it may lead to vascular reperfusion. According to numerous data presented during the 15th Congress of the International Society on Thrombosis and Haemostasis (1995), the superior indications for the use of thrombolytic therapy are acute myocardial infarction and extensive pulmonary embolism. It is still more frequently used in the therapy of deep venous thrombosis and occlusions of peripheral arterial vessels. Treatment of cerebral stroke with thrombolytic agents is under experimental studies. The development of modern techniques in molecular biology, genetic engineering and biotechnology has led to the 'eruption' of quite new perspectives in thrombolytic pharmacology.

Keywords

EN

ANTITHROMBOTIC AGENT; CARDIOVASCULAR DISEASE; THROMBOLYTIC AGENT

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 1999
• Issue: 1
• Pages: 34-44

Contributors

author

T. Pietrucha

author

J. Szemraj

• Publication order reference: T. Pietrucha, Pracownia Biotechnologii Medycznej, Zaklad Biochemii, Akademia Medyczna, ul. Lindleya 6, 90-131 Lodz, Poland, e-mail: [e-mail]