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1999 | 40 | 4 | 343-353
Article title

Constitutional chromosome instability in families with patients affected by sporadic non-hereditary retinoblastoma

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Languages of publication
EN
Abstracts
EN
It has been suggested that chromosome instability is a constitutional factor which may be characteristic of families with an increased risk for the development of malignancies. In this study spontaneous chromosome aberrations, sister chromatid exchanges (SCEs) and chromosome sensitivity to bleomycin were analysed in cultured lymphocytes from 13 families with sporadic non-hereditary unilateral retinoblastoma patients. The significantly increased chromosome instability was detected only by the bleomycin test. Higher mean values of breaks/cell were found in all groups of relatives: patients, parents and siblings.
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Year
Volume
40
Issue
4
Pages
343-353
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Contributors
author
author
author
author
References
Document Type
article
Publication order reference
S. Zajaczek, Department of Genetics and Pathomorphology-Hereditary Cancer Centre, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-b7ff5b03-3afe-3d8f-aabe-80c1c218db4d
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