PL EN


Preferences help
enabled [disable] Abstract
Number of results
2002 | 43 | 4 | 545-553
Article title

Significance of chromosomal markers in the diagnosis of mantle cell lymphoma (MCL)

Title variants
Languages of publication
EN
Abstracts
EN
According to the REAL/WHO classification, the diagnosis of mantle cell lymphoma (MCL) should be based on clinical, histopathological, immunological and cytogenetic or molecular data. This study is based on 13 cases, which were initially diagnosed as MCL with the use of conventional cytogenetic method and fluorescent in situ hybridization (FISH). MCL is associated with a specific cytogenetic aberration t(11;14)(q13;q32). The chromosomal analyses confirmed the MCL diagnosis in four cases. A neartetraploid cell line and two copies of t(11;14) were observed in three cases. These results correspond with a blastoid variant of MCL, accompanied by aggressive course and poor prognosis. The presence of karyotype with t(11;14) as the sole anomaly predicts an intermediate clinical outcome. Six patients had normal karyotypes, which is characteristic for the typical form of MCL, associated with a better prognosis. In this study we show that detection of chromosomal abnormalities is useful in diagnosis of MCL and has some prognostic significance.
Discipline
Publisher

Year
Volume
43
Issue
4
Pages
545-553
Physical description
Contributors
References
Document Type
SHORT COMMUNICA
Publication order reference
R. Woroniecka, Centre of Oncology, M. Sklodowska-Curie Memorial Institute, Cytogenetic Department, ul. Roentgena 5, 02-781 Warszawa, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-b5eae614-72bc-32ca-9fc2-1d070f5a0917
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.