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Journal
2006 | 1 | 151-158
Article title

Production of pigs used in xenotransplantation

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Languages of publication
PL
Abstracts
EN
There are four main trends in the use of transgenic animals. One of the most interesting is the use of transgenic animals as the donors of tissue or organs suitable for transplantation in human ? xenotransplantation. This field of research has been undergoing intensive and increasing study during the past few years, and some encouraging progress is being made. A pig has been identified as the most suitable donor animal. The aim of the presented experiment was to produce transgenic pigs which tissues and organs could be used for the xenotransplantation needs. To target the goal, a competitive gene construct coding the same substrate as the endogenous enzyme of organ donor was introduced. In effect, transgenic boar was produced with confirmed integration of human a1,2 fucosyltransferase gene. Also, F1 generation of transgenic pigs was generated to preserve ongoing needs of preliminary research of xenotransplantation project.
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Journal
Year
Issue
1
Pages
151-158
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References
Document Type
ARTICLE
Publication order reference
Jacek Jura, Dzial Biotechnologii Rozrodu Zwierzat, Instytut Zootechniki, 32-083 Balice k. Krakowa, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-b4c5e093-7882-3d3c-8af8-82cb52dcf844
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