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2003 | 51 | 3 | 179-184
Article title

Immunosuppressive agents and cytomegalovirus infection

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Languages of publication
EN
Abstracts
EN
Cytomegalovirus (CMV) infection is the major infectious complication observed after organ transplantation. As rejection episodes always occur in allograft-transplanted recipients, various kinds of immunosuppressive agnets are used to control such rejection episodes. Among the commonly used immunosuppressive agents, anti-pan T cell monoclonal antibody (OKT3) is known to increase the risk of viral infections. A new immunological techniques have recently been developed to measure CMV-specific CD4 and CD8 cells by flowcytometry. Using the techniques, the high frequencies of specific CD4 and CD8 T cells have been shown to be required to survey the CMV (re)activation in the persistent/latent phase of CMV infection. An excessive T cell depletion by OKT would deplete such surveying T cells, thus resulting in the occurrence of CMV-associated diseases.
Publisher

Year
Volume
51
Issue
3
Pages
179-184
Physical description
Contributors
author
References
Document Type
REVIEW
Publication order reference
K.Tanaka, Department of Infectious Diseases, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-b4a59bc0-e948-3dff-92c3-2fe1c98fec38
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