The use of E.coli cytosine deaminase gene as an example of suicide gene therapy of cancer

• Authors: E. Missol , A. Sochanik , S. Szala
• Languages of publication: EN

Abstracts

EN

Suicide genes encode enzymes, which convert nontoxic substrates to toxic products.These genes are proposed for selective killing of tumor cells in cancer gene therapy.In this review we demonstrate preliminary results of direct in vivo transfer of cytosine deaminase (CD) gene from E.coli into murine B16(F10) melanoma cells via cationic liposomes.

Keywords

EN

CYTOSINE DEAMINASE GENE; GENE THERAPY; LIPOSOME; MELANOMA CELL

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 1996
• Issue: 4
• Pages: 80-90

Contributors

author

E. Missol

author

A. Sochanik

author

S. Szala

• Document Type: article
• Publication order reference: S.Szala, Dept. of Tumor Biology, Institute of Oncology, Wybrzeze Armii Krajowej St. 15, 44-100 Gliwice, Poland