Cathepsin B and pro-drug activation

• Authors: M. Warwas
• Languages of publication: PL

Abstracts

EN

Cathepsin B (CB) is a tumour-associated cysteine peptidase, which plays an important role in the proteolytic cascade involved in cancer invasion. Therefore, pro-drugs specifically activated by CB are expected to possess enhanced tumour selected properties. This paper presents the actual stage of knowledge on anticancer therapy strategies using CB as a side-specific activator of immuno- or polymer-conjugates (Antibody Directed Enzyme Pro-Drug Therapy or Polymer Directed Enzyme Pro-Drug Therapy, respectively). Usefulness of CB determinations in the laboratory diagnosis of neoplastic diseases is also presented.

Keywords

EN

ANTICANCER THERAPY   CATHEPSIN B  

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International; Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2003
• Volume: 57
• Issue: 6
• Pages: 701-712
• Document Type: ARTICLE
• Publication order reference: M. Warwas, Katedra i Zak?ad Biochemii Farmaceutycznej AM, ul. Szewska 38, 50-139 Wroc?aw, Poland