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2003 | 57 | 6 | 701-712
Article title

Cathepsin B and pro-drug activation

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PL
Abstracts
EN
Cathepsin B (CB) is a tumour-associated cysteine peptidase, which plays an important role in the proteolytic cascade involved in cancer invasion. Therefore, pro-drugs specifically activated by CB are expected to possess enhanced tumour selected properties. This paper presents the actual stage of knowledge on anticancer therapy strategies using CB as a side-specific activator of immuno- or polymer-conjugates (Antibody Directed Enzyme Pro-Drug Therapy or Polymer Directed Enzyme Pro-Drug Therapy, respectively). Usefulness of CB determinations in the laboratory diagnosis of neoplastic diseases is also presented.
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ARTICLE
Publication order reference
M. Warwas, Katedra i Zak?ad Biochemii Farmaceutycznej AM, ul. Szewska 38, 50-139 Wroc?aw, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-b1155181-3ceb-3cd5-baf0-f155094c127c
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