The patch-clamp technique in investigations on T lymphocyte potassium channel modulation
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This review focuses on results of patch-clamp studies on modulation of T lymphocyte potassium channel activity by physiologically relevant factors. In the preface the patch-clamp technique is briefly presented and basic properties of potassium channels in T lymphocytes are characterised. The paper contains an overview of the data on modulatory effects of extracellular and intracellular pH, temperature, extracellular potassium, extracellular divalent and trivalent metal cations, channel phosphorylation processes and membrane lipid metabolities on potassium channel activity. Some still unresolved problems in that area are indicated.
Publication order reference
A.Teisseyre, Katedra i Zaklad Biofizyki Akademii Medycznej, ul. Chalubinskiego 10, 50-368 Wroclaw, Poland