PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 68 | 3 | 347-353
Article title

Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats

Selected contents from this journal
Title variants
Languages of publication
EN
Abstracts
EN
Nigrostriatal neurons expressing RET protein, a receptor protein tyrosine kinase of glial cell line-derived neurotrophic factor (GDNF), were investigated in rats using retrograde neural tracing with horseradish peroxidase (HRP) combined with immunohistochemistry. HRP/RET double-labeled neurons were abundantly distributed in the substantia nigra pars compacta ipsilateral to the caudate-putamen stereotaxically injected with HRP. Almost all the HRP-labeled neurons in nigra exhibited RET-like immunoreactivity, which however constituted more than half of the RET-immunoreactive cells. Our results present morphological evidence that GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals.
Contributors
author
author
author
author
author
author
author
References
Document Type
ARTICLE
Publication order reference
Guo-Dong Gao, Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, P.R. China
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-b01b55c6-6297-3a61-b535-f9d1ba2b5abf
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.