Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats

• Authors: S.-M. He , Z.-W. Zhao , L. Zhao , X.-L. Wang , D. Jia , F. Hou , G.-D. Gao
• Languages of publication: EN

Abstracts

EN

Nigrostriatal neurons expressing RET protein, a receptor protein tyrosine kinase of glial cell line-derived neurotrophic factor (GDNF), were investigated in rats using retrograde neural tracing with horseradish peroxidase (HRP) combined with immunohistochemistry. HRP/RET double-labeled neurons were abundantly distributed in the substantia nigra pars compacta ipsilateral to the caudate-putamen stereotaxically injected with HRP. Almost all the HRP-labeled neurons in nigra exhibited RET-like immunoreactivity, which however constituted more than half of the RET-immunoreactive cells. Our results present morphological evidence that GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals.

Keywords

EN

GLIAL CELL; HORSERADISH PEROXIDASE; IMMUNOHISTOCHEMISTRY; SUBSTANTIA NIGRA

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2008
• Volume: 68
• Issue: 3
• Pages: 347-353

Contributors

author

S.-M. He

author

Z.-W. Zhao

author

L. Zhao

author

X.-L. Wang

author

D. Jia

author

F. Hou

author

G.-D. Gao

• Document Type: ARTICLE
• Publication order reference: Guo-Dong Gao, Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, P.R. China