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2002 | 56 | 2 | 155-167
Article title

Tioredoxin reductase ? a new target for molecular medical investigations

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PL
Abstracts
EN
Thioredoxin reductase (TrxR) is the first selenoenzyme containing selenocysteine in the active center and FAD as a second prosthetic group. TrxR catalyses the NADPH-dependent reduction of tioredoxin and of many other physiologically important substrates. TrxR exhibits many-fold increased activity in tumor cells and stimulates their proliferation as well the phenotype changes. Some gold compounds and a number of other clinically and experimentally used drugs have been shown to inhibit TrxR. The involvement of TrxR/Trx/NADPH system in broad spectrum of cellular processes renders it potential target for therapeutic approaches.
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ARTICLE
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P. Zagrodzki, Zaklad Bromatologii CM UJ, ul. Medyczna 9, 30-688 Krakow, Poland
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bwmeta1.element.element-from-psjc-a96da3f0-de23-3186-b692-458a5091b8c8
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