PL EN


Preferences help
enabled [disable] Abstract
Number of results
1996 | 56 | 1 | 281-285
Article title

Chromatin structure and transcriptional activity of MAG gene

Authors
Selected contents from this journal
Title variants
Languages of publication
EN
Abstracts
EN
Myelin associated glycoprotein (MAG) is an essential component of the periaxonal architecture of the myelin sheath. Because of its potent neurite growth repressive activity, MAG is also likely to play an important role in axonal guidance during the CNS development, and to be responsible for abortive neuronal regeneration in adult CNS. The MAG gene chromatin from approximately -1.6 to +0.6 kb features MNase hypersensitivity that maydelineate the gene control region. The proximal upstream region of the gene is organized into an array of five nucleosomes with hypersensitive linkers. The core promoter is located within the first upstream linker that becomes highly hypersensitive in the course of oligodendrocyte differentiation. The adjacent upstream region contains positive and negative enhancers that are likely to streamline oligodendrocyte specific expession of the gene. The TATA-less core promoter contains novel, as yet uncharacterized initiator elements that direct the assembly of transcriptional complexes. The promoter appears to be controlled by both, the addition of activating trans-factors as progenitor cells differentiate into mature oligodendrocyte. The developmental activation of the gene is also concomitant with profound DNA demethylation that may provide auxiliary regulatory mechanisms. Hence, the upregulation of the MAG gene is differentiating oligodendrocytes entails chromantic remodeling as well as changes in the assortment of nuclear trans-factors.
Publisher

Year
Volume
56
Issue
1
Pages
281-285
Physical description
Contributors
author
References
Document Type
proceeding
Publication order reference
G.W.Konat
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-a7f3266c-626d-3e40-ae9a-8636ec917397
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.