Sjogren's syndrome: immunological response underlying the disease

• Authors: J.B. Brayer , M.G. Humphreys-Beher , A.B. Peck
• Languages of publication: EN

Abstracts

EN

Sjogren's syndrome is a chronic autoimmnune disorder characterized primarily by the discomforts od dry eyes and dry mouth due to the progressive loss of exocrine gland function. Development of a number of animal models to study Sjogren's syndrome, especially the NOD mouse and its congenic partner strains, has permitted a systematic analysis of immunological and non-immunological factors that influence predisposition for development of the autoimmune response. These data are reviewed here.

Keywords

EN

AUTOANTIBODY   AUTOIMMNUNE DISORDER   AUTOIMMUNE EXOCRINOPATHY   CYTOKINE  

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 5
• Pages: 353-360
• Document Type: REVIEW
• Publication order reference: J.B.Brayer, Department of Oral Biology and Pathology, Laboratory Science and Center for Orphaned Autoimmune Diseases, University of Florida, Gainesville, FL 32610, USA