Chemical modifications of macromolecules and their use in the preparation of protein antitumor drug conjugates, vaccines and diagnostic reagent
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This article reviews high temperature glycation of proteins, and describes some applications of thus recived neoglycoconjugates as vaccines or drug and gene carriers. The use of macromolecules: antibodies, fibrinogen and natural or synthetic polymers as antitumor drug carriers is discussed. Moreover the article presents method for monitoring of proteins modification by glutaraldehyde.
Publication order reference
J. Boratynski, Instytut Immunologii i Terapii Doswiadczalnej PAN, ul R.Weigla 12, 53-114 Wroclaw, Poland