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2008 | 56 | 2 | 123-126
Article title

Live attenuated Leishmania vaccines: a potential strategic alternative

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Languages of publication
EN
Abstracts
EN
Leishmaniasis causes significant morbidity and mortality worldwide, constituting an important public health problem. Leishmania infections cause a wide spectrum of diseases, ranging in severity from spontaneously healing skin lesions to fatal visceral disease. Attempts to develop an effective vaccine to control leishmaniasis have been shown to be feasible, but no vaccine is in active clinical use. The ability to create genetically modified parasites by eliminating virulence or essential genes is considered a powerful alternative in the development of an effective protective vaccine. Here, recent findings related to genetically defined live attenuated Leishmania parasites as promising vaccine candidates are reviewed.
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Publisher

Year
Volume
56
Issue
2
Pages
123-126
Physical description
Contributors
References
Document Type
MINIREVIEW
Publication order reference
Ali Ouaissi, INSERM, UMR 554, CNRS 5048, Centre de Biochimie Structurale, Montpellier, 29 rue de Navacelle, 34090, Montpellier Cedex, France
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YADDA identifier
bwmeta1.element.element-from-psjc-a3d401e1-f02c-38ad-a069-f4f361ee59cd
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