Molecular and cellular basis of <cis-DDP> <DNA> interactions

• Authors: Tomasz H. Zastawny , Ryszard Olinski
• Languages of publication: PL

Abstracts

EN

Cis-DDP is an <antitumor drug> with activity against various <human tumors>. It is generally accepted that <DNA> is the <cellular target> of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eucariotic systems. We also discuss the possible mechanisms of acquired <resistance> of <cancerous cells> to cis-DDP and analoques, and potential clinical implication of this fenomenon.

Keywords

EN

DNA ADDUCT; DRUG RESISTANCE; HUMAN TUMOR; TUMOR CHEMOTHERAPY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1993
• Volume: 47
• Issue: 2
• Pages: 101-121

Contributors

author

Tomasz H. Zastawny

author

Ryszard Olinski

• Document Type: article
• Publication order reference: Tomasz H. Zastawny