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1993 | 47 | 2 | 101-121
Article title

Molecular and cellular basis of <cis-DDP> <DNA> interactions

Title variants
Languages of publication
PL
Abstracts
EN
Cis-DDP is an <antitumor drug> with activity against various <human tumors>. It is generally accepted that <DNA> is the <cellular target> of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eucariotic systems. We also discuss the possible mechanisms of acquired <resistance> of <cancerous cells> to cis-DDP and analoques, and potential clinical implication of this fenomenon.
Publisher

Year
Volume
47
Issue
2
Pages
101-121
Physical description
Contributors
References
Document Type
article
Publication order reference
Tomasz H. Zastawny
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-9e8fe23d-ca4d-3f19-ac0a-41ab1d487b50
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