Predicting outcome in haematological stem cell transplantation

• Authors: A.M. Dickinson , J. Cavet , H. Cullup , X.N. Wang , M. Jarvis , L. Sviland , P.G. Middleton
• Languages of publication: EN

Abstracts

EN

This present review summarises recent results investigating the role of certain cytokine gene polymorphisms, including TNF, IFN, IL-6, IL-10 and IL1 Ra, in allogeneic stem cell transplantation. The review discusses their role in predicting outcome and the development of a genetic risk index for Graft versus Host Disease in HLA matched sibling transplants. By the comparative use of an in vitro human skin explant model initial results suggest that certain cytokine gene polymorphisms may be associated with more severe disease.

Keywords

EN

CYTOKINE; GENE POLYMORPHISM; STEM CELL; TRANSPLANTATION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 6
• Pages: 369-376

Contributors

author

A.M. Dickinson

author

J. Cavet

author

H. Cullup

author

X.N. Wang

author

M. Jarvis

author

L. Sviland

author

P.G. Middleton

• Document Type: REVIEW
• Publication order reference: A.M. Dickinson, University Departmentt Haematology, Tyneside Leukaemia Research Laboratory, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK