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2002 | 62 | 1 | 1-5
Article title

Proteolysis of endomorphin-1 by brain synaptic membrane-associated peptidases

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EN
The biotransformation of endomorphin-1 (EM-1) by brain synaptic membranes has been studied. Peptide fragments of EM-1 that were formed during incubation with membrane preparations in vitro were isolated by High-performance liquid chromatography (HPLC) and characterized using determination of amino acid composition. At pH 7.4, two degradation products, EM-1(1-3) and EM-1(1-2), were identified. EM-1 was degraded 77.5% at 30 min incubation with synaptic membranes. The time course of the experiments and the effect of carboxypeptidase inhibitor (CPI) demonstrated that the proteolysis reaction involves the participation of carboxypeptidase activity.
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62
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1
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1-5
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ARTICLE
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J. Chen, Pharmaceutic Biotechnology Key Laboratory, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China
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bwmeta1.element.element-from-psjc-9a8d01d2-e20e-36f8-85b4-bb4801372afc
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