Protein kinase C: a nexus in the biochemical events that underlie associative learning

• Authors: James L. Olds , Daniel L. Alkon
• Languages of publication: EN

Abstracts

EN

We have proposed that protein kinase C, an enzyme critical to cell regulation of growth, secretion and differentiation, is a part of a sequence of molecular events that unsderlie learning and memory. Electrophysiological, biochemical and neuro-imaging methods have been employed to show that the enzyme changes its distribution as a result of memory storage within the neural networks that are necessary for the acquisition and performance of various learning tasks in several species. We propose here, a model of protein kinase C as a molecular signal for the association of synaptic input that is parsimonious with the recent data, mainly our laboratory, concerning its function in emory formation.

Keywords

EN

ASSOCIATION; HERMISSENDA CRASSIOCORNIS; HIPPOCAMPUS; LEARNING; MEMORY; NICTITATING MEMBRANE; PROTEIN KINASE C; RABBIT; SECOND MESSENGER SYSTEM

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1993
• Volume: 53
• Issue: 1
• Pages: 197-207

Contributors

author

James L. Olds

author

Daniel L. Alkon

• Document Type: paper