Organotins are ubiquitos in the environment. They are commonly used as a component of plant protective agents, antifouling paints, PVC stabilisers, catalyst and wood preservatives. Some organotins show deleterious effects on different organisms even at very low concentration. Of particular importance to the environment is high toxicity of tributyltin (TBT). Biotransformation of organotin compounds by dealkylation or methylation has been observed. This paper focused on the interactions of microorganisms with organotins including bioaccumulation, detoxification and degradation.