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1993 | 45 | 1 | 95-100
Article title

Synthesis and cardiotonic evaluation of R-sulfonyl derivatives of azaheterocycles

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EN
Abstracts
EN
A series of alfa-sulfonyl-2-(-chloro)hetarylacetonitriles was prepared by the interaction of dichlorodiazines and R-sulfonylacetonitriles. Reaction of nucleophilic substitution of chlorine by different N-H-azoles has been studied. The compounds obtained showed 3 types of activity on cardiac papillary muscles: 1. a biphasic activity with increase in cardiac contractility at low concentration and inhibition in high concentration (1, 2, 4, 12-15), 2. a monophasic inhibitory activity (3, 5, 8-10), 3. non-active compounds (6, 7, 11). The preliminary SAR studies indicate the importance of chlorine atom at position 3 in diazine nucleus and of alkyl substituents in benzimidazole moiety for positive inotropic effects.
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Year
Volume
45
Issue
1
Pages
95-100
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article
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YADDA identifier
bwmeta1.element.element-from-psjc-98e45365-9d0a-39ff-ba39-c4bd12b4ba9d
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