Control of immune responses by immunoregulatory T cells

• Authors: G. Rudge , P.A. Gleeson , Driel J.R. van_
• Languages of publication: EN

Abstracts

EN

Immunoregulatory T cells play a key role in modifying the immune responses to self antigens, tumor antigens, and pathogenic organisms. This review summarizes recent data on naturally occurring CD4+ regulatory T cells that constitutively express CD25 (CD25+ Treg). We examine the markers that can be used to differentiate these cells from effector T cells, what is known about their mode of action in controlling the activity of effector T cells, the antigenic specificity of CD25+ Treg, and their ability to survive and to be selected in vivo. We also summarize specific information on the role of CD25+ Treg in controlling anti-tumor responses, an area were manipulation of this subset holds particular clinical promise.

Keywords

EN

IMMUNOREGULATION; REGULATORY T CELL; TUMOR IMMUNITY

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2006
• Volume: 54
• Issue: 6
• Pages: 381-391

Contributors

author

G. Rudge

author

P.A. Gleeson

author

Driel J.R. van_

• Document Type: REVIEW
• Publication order reference: Ian R. van Driel, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia