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Journal
2006 | 2 | 148-165
Article title

Epithelial cell cultures as a model system to study the transepithelial transport

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PL
Abstracts
EN
Epithelial cell lines are commonly accepted model system to determine intestinal permeability and transepithelial transport. The application of Caco-2 human epithelial cell culture can be used to study bioavailability of drug and food compounds. This culture grows on porous membranes and forms a monolayer of well differentiated cells joined by intracellular tight junctions. This system provides selective barrier to study passive and active transport of different molecules. The Caco-2 cells posses some enzymes and transport systems similar to intestinal epithelium in vivo, however, these proteins are expressed to a lesser extent compared to normal enterocytes. In this paper, the advantages and limitations of Caco-2 model are discussed.
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Journal
Year
Issue
2
Pages
148-165
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author
author
References
Document Type
REVIEW
Publication order reference
Wlodzimierz Grajek, Katedra Biotechnologii i Mikrobiologii Zywnosci, Akademia Rolnicza im. Augusta Cieszkowskiego, ul. Wojska Polskiego 48, 60-627 Poznan, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-97e98f39-b31b-346c-b4f9-4af3da0bc938
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