Respiratory effects of capsaicin occur beyond the lung vagi in anaesthetized rats

• Authors: K. Kaczynska , M. Szereda-Przestaszewska
• Languages of publication: EN

Abstracts

EN

The effects of an intravenous capsaicin challenge on the respiratory pattern and ventilation were studied in 15 urethane/chloralose-anaesthetized, spontanously breathing rats. Bolus injection of capsaicin at a dose of 5 mug/kg into the right femoral vein evoked respiratory arrest in all animals (both prior to and after bilateral midcervical vagotomy), which effect was abolished by ruthenium red pretreatment. Breathing that followed the apnoea was of enlarged tidal volume and initially increased respiratory rate, which resulted in an augmented ventilation. The capsaicin-induced respiratory changes were independent of vagal integrity and may depend on stimulation of vanilloid receptors within the nodose ganglia.

Keywords

EN

APNOEA; BREATHING CONTROL; CAPSAICIN; RAT; VAGUS NERVE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2000
• Volume: 60
• Issue: 2
• Pages: 159-165

Contributors

author

K. Kaczynska

author

M. Szereda-Przestaszewska

• Document Type: article
• Publication order reference: K. Kaczynska, Department of Neurophysiology, Medical Research Centre, Polish Academy of Sciences, 5 Pawinski St., 02-106 Warsaw, Poland, Email: [e-mail]