Effects of acetylsalicylic acid and a new pyrazine derivative PD-101 on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes
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Acetylsalicylic acid (ASA) and ?-2-pyrazylidene-?-cyano N-butyl acetamide (PD-101), a new antiaggregatory pyrazine derivative were tested for their genotoxicity in human lymphocytes in vitro using the sister chromatid exchange (SCE) technique. Both compounds were found to be inactive in inducing SCE in concentration from 1muM up to 1000 muM. The agents displayed inhibitory effect on cell kinetics.
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A. Wozniak, Department of Biology and Genetics, Medical University, ul. Debinki 1, 80-210 Gdansk, Poland