Human cord blood cells can differentiate into retinal nerve cells

• Authors: N. Koike-Kiriyama , Y. Adachi , K. Minamino , M. Iwasaki , K. Nakano , Y. Koike , H. Yamada , H. Mukaide , A. Shigematsu , T. Mizokami , M. Matsumura , S. Ikehara
• Languages of publication: EN

Abstracts

EN

Retinal degeneration and dystrophy are the major causes of blindness in the developed world. It has been reported that human cord blood cells (HCBCs) can differentiate into neuron-like cells in vitro. We have recently demonstrated that bone marrow cells (BMCs) of both mice and rats can differentiate into retinal nerve cells (RNCs). In the present study, we show the differentiation capacity of HCBCs into RNCs in vivo. We transplanted lineage-negative HCBCs into the subretinal space of severe combined immunodeficiency (SCID) mice. Two weeks after the transplantation, some of the transplanted cells expressed human nestin, human MAP2, human neuron specific enolase (NSE), beta-III tubulin and also rhodopsin. These results indicate that HCBCs can differentiate into RNCs and suggest that our new strategy could be used for the regeneration of retinal nerve cells in degenerative or dystrophic diseases.

Keywords

EN

CORD BLOOD; DYSTROPHY; HUMAN; REGENERATION; RETINAL DEGENERATION; STEM CELL

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2007
• Volume: 67
• Issue: 4
• Pages: 359-365

Contributors

author

N. Koike-Kiriyama

author

Y. Adachi

author

K. Minamino

author

M. Iwasaki

author

K. Nakano

author

Y. Koike

author

H. Yamada

author

H. Mukaide

author

A. Shigematsu

author

T. Mizokami

author

M. Matsumura

author

S. Ikehara

• Document Type: ARTICLE
• Publication order reference: S. Ikehara, First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka 570-8506, Japan