PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2002 | 1 | 57-70
Article title

Strategy of directed RNA degradation and selected examples of its use in antiviral therapy

Title variants
Languages of publication
PL
Abstracts
EN
Over the last decade, antisense oligodeoxynucleotides and ribozymes have emerged as valuable biochemical tools and promising therapeutic reagents in medicine. This review describes the basic principles of their use in the strategy of directed RNA degradation. The rules for the rational choice of targeted RNA sequences, the properties of available RNA cleaving tools, as well as the major problems that limit the effectiveness of this new technology, are discussed. Selected examples of the successful use of antisense oligonucleotides and ribozymes as antiviral agents are presented.
Publisher

Journal
Year
Issue
1
Pages
57-70
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
J. Ciesiolka, Instytut Chemii Bioorganicznej, Polska Akademia Nauk, ul. Noskowskiego 12/14, 61-704 Poznan, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-926effd6-06f9-3d59-a527-f105832772ae
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.