Strategy of directed RNA degradation and selected examples of its use in antiviral therapy
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Over the last decade, antisense oligodeoxynucleotides and ribozymes have emerged as valuable biochemical tools and promising therapeutic reagents in medicine. This review describes the basic principles of their use in the strategy of directed RNA degradation. The rules for the rational choice of targeted RNA sequences, the properties of available RNA cleaving tools, as well as the major problems that limit the effectiveness of this new technology, are discussed. Selected examples of the successful use of antisense oligonucleotides and ribozymes as antiviral agents are presented.
Publication order reference
J. Ciesiolka, Instytut Chemii Bioorganicznej, Polska Akademia Nauk, ul. Noskowskiego 12/14, 61-704 Poznan, Poland