PL EN


Preferences help
enabled [disable] Abstract
Number of results
1999 | 59 | 1 | 15-22
Article title

Behavioral and neurochemical alterations evoked by p-Chlorophenylalanine application in rats examined in the light-dark crossing test

Selected contents from this journal
Title variants
Languages of publication
Abstracts
EN
The aim of the present study is to examine the effects of serotonin synthesis inhibition with p-Chlorophenylalanine (p-CPA) in rats on (1) anxiety behavior examined in the light-dark crossing test and, (2) regional brain concentration of monoamines (NA, DA and 5-HT) and their metabolites (MHPG, DOPAC, HVA and 5-HIAA) as well as GABA in the hypothalamus, amygdala, hippocampus, midbrain central gray matter and the frontal cortex. Treatment of animals with p-CPA produced a significant increase in time out from the illuminated part of the chamber and in time of locomotor activity in the illuminated part of the chamber. HPLC analysis showed a significant reduction of 5-HT and 5-HIAA concentration in all examined brain regions with the exception of the frontal cortex. Additionally, a significant decrease in DA and its metabolites, DOPAC and HVA occurred in the hypothalamus and amygdala. Moreover, we observed a significant decrease in frontal cortex NA concentration after p-CPA administration. The results of our study suggest that administration of p-CPA is effective in reduction of anxiety through depletion of 5-HT accompanied by diminution of catecholamines, especially DA and its metabolites in the main emotional brain regions.
Keywords
EN
Publisher

Year
Volume
59
Issue
1
Pages
15-22
Physical description
Contributors
author
author
author
author
author
References
Document Type
Publication order reference
A. Romaniuk, Department of Neurophysiology, University of Lodz, 66 Rewolucji 1905 r. St., 90-222,Lodz, Poland, Email: marek@biol.uni.lodz.pl
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-905150b8-2215-3fdb-9415-5b2c67149bea
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.