Role glyoxales and methyglyoxal in cell proliferation and differentiation

• Authors: D. Piskorska , R. Grabowska-Bochenek
• Languages of publication: PL

Abstracts

EN

The glyoxalase system catalases the conversion of methylglyoxal (and other 2-ketoaldehydes) to D-latic acid via teh intrmediate S-D-lactoglutathione.It comprises two enzymes, glyoxalases I and glyoxalases II, and catalytic amount to reduced glutathione.Methylglyoxal inhibits cell growth, while the glyoxalase system by breaking down methylglyoxal may act as a promoter of cell growth.Inhibitors of glyoxalase may serve as possible therapeutic agents against cancer by virtue of their ability to elevate the level of methylglyoxal in the body.

Keywords

EN

CELL PROLIFERATION; GLYOXALASE; METHYLGLYOXAL; S-D-LACTOYLGLUTATHIONE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1995
• Volume: 49
• Issue: 3
• Pages: 433-444

Contributors

author

D. Piskorska

author

R. Grabowska-Bochenek

• Document Type: article
• Publication order reference: D.Piskorska