The interactions of T lymphocytes with elastin and their significance in immunopathology

• Authors: M. Targonska , A. Gorski , M. Kasprzycka , M. Nowaczyk
• Languages of publication: PL

Abstracts

EN

Recent data indicate that human T lymphocytes can adhere to elastin and respond to co-stimulatory signals of that protein. This reactivity is mediated by non-integrin receptor, elastin binding protein. In addition, another receptor belonging to integrin family may be also involved. T cell interactions with elastin (but not other extracellular matrix proteins) appear to be upregulated in healthy males and at least patients with vasculitis. Interestingly, statins in pharmacological concentrations strongly and selectively block those interactions. Our data point to the potential role of T cell interactions with elastin in immunopathology of vasculitis and atherosclerosis.

Keywords

EN

ELASTIN; IMMUNOPATHOLOGY; T LYMPHOCYTE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 1
• Pages: 3-10

Contributors

author

M. Targonska

author

A. Gorski

author

M. Kasprzycka

author

M. Nowaczyk

• Document Type: ARTICLE
• Publication order reference: M. Targonska, Instytut Immunologii i Terapii Doswiadczalnej PAN, ul. R.Weigla 12, 53-114 Wroclaw, Poland