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2001 | 49 | 4 | 303-310
Article title

Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth

Authors
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Languages of publication
EN
Abstracts
EN
Transplantation has emerged as an effective treatment for patients with end-stage organ failure. Current regimens of non-specific immunosuppressive drug treatment, which are needed life-long to prevent graft rejection, have numerous adverse side effects and increase the risk of opportunistic infections and malignancy. A major goal is to develop immunotherapeutic protocols that achieve specific tolerance. Such protocols would decrease and eventually eliminate the reliance on non-specific drug therapy. We showed that portal vein (pv) delivery of donor antigen prolongs the survival of vascularized and non-vascularized allo- and xeno-grafts, and that increased graft survival is associated with altered cytokine production and augmented expression of the molecule OX2. This review documents further evidence for a more general immunoregulatory role for the interactions of OX2 and its ligand, OX2L.
Publisher

Year
Volume
49
Issue
4
Pages
303-310
Physical description
Contributors
References
Document Type
REVIEW
Publication order reference
R.M. Gorczynski, CCRW 2-855, The Toronto Hospital, University Health Network, Toronto, Canada
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-8c3c80fb-4496-3a35-ba33-36bc4ea2140e
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