Clinical and genetic heterogeneity of rheumatoid arthritis

• Authors: P.A. Klimiuk , C.M. Weyand , S. Sierakowski , J.J. Goronzy
• Languages of publication: PL

Abstracts

EN

The diagnostic category of rheumatoid arthritis, a syndrome of chronic inflammatory disease of the synovial membrane and of extraarticular tissues, covers a broad spectrum of clinical phenotypes. Here we propose that distinct combinations of disease risk genes produce heterogeneity of rheumatoid disease. Recognition of this genetic and clinical heterogeneity has immediate implications as it provides the opportunity to develop selective therapies for the different variants of disease.

Keywords

EN

HETEROGENEITY; RHEUMATOID ARTHRITIS

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2000
• Volume: 54
• Issue: 6
• Pages: 845-853

Contributors

author

P.A. Klimiuk

author

C.M. Weyand

author

S. Sierakowski

author

J.J. Goronzy

• Document Type: ARTICLE
• Publication order reference: P. A. Klimiuk, Klinika Reumatologii i Chorob Wewnetrznych AM, ul. M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland