Few associations of candidate genes with nonsyndromic orofacial clefts in the population of Lithuania

• Authors: A. Morkunienc , D. Steponaviciutc , A. Utkus , V. Kucinskas
• Languages of publication: EN

Abstracts

EN

Nonsyndromic orofacial clefting (NS-OFC) is a common complex multifactorial trait with a considerable genetic component and a number of candidate genes suggested by various approaches. Twenty biallelic and microsatellite DNA markers in the strong candidate loci TGFA, TGFB3, GABRB3, RARA, and BCL3 were analysed for allelic association with the NS-OFC phenotype in 112 nuclear families (proband + both parents) from Lithuania by using the transmission disequilibrium test (TDT). Associations were found between the TGFA gene marker rs2166975 and nonsyndromic cleft palate only (CPO) phenotype (p = 0.045, df 1) as well as between the D2S292 marker and the cleft lip with or without cleft palate (CL/CP) phenotype in allele-wise TDT (P = 0.005, df 9) and genotype-wise TDT (P = 0.021, df 24). A weak association (P = 0.085, df 3) of the BCL3 marker (BCL3 gene) with the risk of CPO was also found. Thus our initial results support the contribution of allelic variation in the TGFA locus to the aetiology of CL/CP in the population of Lithuania but they do not point to TGFA as a major causal gene. Different roles of the TGFA and BCL3 genes in the susceptibility to NS-OFC phenotypes are suggested.

Keywords

EN

ALLELIC ASSOCIATION; CANDIDATE GENE; NONSYNDROMIC OROFACIAL CLEFTS

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 2007
• Volume: 48
• Issue: 3
• Pages: 89-91

Contributors

author

A. Morkunienc

author

D. Steponaviciutc

author

A. Utkus

author

V. Kucinskas

• Document Type: ARTICLE
• Publication order reference: V. Kucinskas, Department of Human and Medical Genetics, Faculty of Medicine, Vilnius University, Santari?kir street 2, LT?08661, Vilnius, Lithuania