Effect of the cholinesterase-inhibiting substance galanthamine on evoked visual potentials in rats

• Authors: M.H. Lewandowski , L. Zmuda
• Languages of publication: EN

Abstracts

EN

We studied the effect of intravenous injection of the cholinesterase inhibitor galanthamine (GAL) in doses from 0.025 to 5.0 mg/kg on electrically evoked field potentials in rat visual cortex.In all the experiments the amplitude of late components of evoked potentials was significantly reduced, while early components remained unaffected.These findings indicate that cortical cells are inhibited by acetylocholine (ACh).Furthermore, combined application of a muscarinic receptor blocker (atropine) and GAL reliably suppressed the effects of galanthamine.These observations suggest that ACh-induced inhibition may be mediated by activation of GABAergic interneurones that possess muscarinc receptors.

Keywords

EN

ACETYLCHOLINE   ACETYLCHOLINESTERASE   ACHE   DORSAL LATERAL GENICULATE NUCLEUS   GALANTHAMINE  

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1995
• Volume: 55
• Issue: 2
• Pages: 141-145
• Document Type: article
• Publication order reference: M.H.Lewandowski