PL EN


Preferences help
enabled [disable] Abstract
Number of results
2003 | 51 | 5 | 295-300
Article title

Viruses as hijackers of PML nuclear body

Title variants
Languages of publication
EN
Abstracts
EN
Promyelocytic leukemia nuclear bodies (PML-NBs) are discrete interchromosomal macromolecular structures. The integrity of this dynamic nuclear subcompartment critically depends on the presence of the name-giving PML protein. Among the permanent or transient residents of PML-NBs are various regulatory proteins, including Sp100, CBP, pRb, HIPK2, RAD51 and p53. PML-NBs are frequently targeted by viral infections, as a number of different RNA and DNA viruses including herpesviruses, adenoviruses, papovaviruses, papillomaviruses and arenaviruses cause changes in PML-NBs. Viruses interfere with PML-NB in two ways: 1) some viral proteins can associate with PML-NB proteins and/or lead to the destruction and lysis of this subnuclear compartment, thus aiding viral gene expression and disabling the host's innate immunity; 2) the parental genomes of some nuclear-replicating DNA viruses associate preferentially with PML-NBs, which presumably serves to assist in viral gene expression or replication. Here we feature the different viral strategies leading to the hijacking of PML-NBs and discuss the consequences for the immune response.
Publisher

Year
Volume
51
Issue
5
Pages
295-300
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
A. Moller, Department of Chemistry and Biochemistry, University of Bern, CH-3012 Bern, Switzerland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-86e5f2ed-21b5-37c8-b14c-3f118a90f1a2
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.