NOTCH1 receptor: structure and role during T-cell development

• Authors: B. Gidzinska
• Languages of publication: PL

Abstracts

EN

The Notch family are proteins which function both as cell surface receptors and regulators of gene transcription. Notch proteins influence cell-fate decisions during lymphopoesis, neurogenesis and myogenesis. During lymphopoesis Notch1 is implicated in differentiation of lymphoid precursor CLP towards T-cells but not B-cells lineage. In spite of earlier results suggesting involvement of Notch1 in commitment towards alpha beta and gamm a delta or CD4 and CD8 T cell lineage, later experiments didn?t confirm this possibility.

Keywords

EN

DEVELOPMENT; NOTCH1 RECEPTOR; STRUCTURE; T-CELL

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2003
• Volume: 57
• Issue: 4
• Pages: 369-376

Contributors

author

B. Gidzinska

• Document Type: ARTICLE
• Publication order reference: B. Gidzinska, Zaklad Immunologii Nowotworow, Instytut Immunologii i Terapii Doswiadczalnej PAN, ul. R. Weigla 12, 53-114 Wroclaw, Poland