NOTCH1 receptor: structure and role during T-cell development
Languages of publication
The Notch family are proteins which function both as cell surface receptors and regulators of gene transcription. Notch proteins influence cell-fate decisions during lymphopoesis, neurogenesis and myogenesis. During lymphopoesis Notch1 is implicated in differentiation of lymphoid precursor CLP towards T-cells but not B-cells lineage. In spite of earlier results suggesting involvement of Notch1 in commitment towards alpha beta and gamm a delta or CD4 and CD8 T cell lineage, later experiments didn?t confirm this possibility.
Publication order reference
B. Gidzinska, Zaklad Immunologii Nowotworow, Instytut Immunologii i Terapii Doswiadczalnej PAN, ul. R. Weigla 12, 53-114 Wroclaw, Poland