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2002 | 50 | 5 | 325-332
Article title

The role of TGF-beta signaling in the pathogenesis of fibrosis in scleroderma

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EN
Abstracts
EN
Excessive extracellular matrix (ECM) deposition in the skin, lung, and other organs is a hallmark of systemic sclerosis (SSc). The pathogenesis of SSc is still poorly understood, but increasing evidence suggests that transforming growth factor (TGF)-beta is a key mediator of tissue fibrosis as a consequence of ECM accumulation in pathologic states such as systemic sclerosis. TGF-beta regulates diverse biological activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis. TGF-beta is known to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. This review focuses on the possible role of TGF-beta in the pathogenesis of fibrosis in SSc.
Publisher

Year
Volume
50
Issue
5
Pages
325-332
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author
References
Document Type
REVIEW
Publication order reference
H. Ihn, Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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YADDA identifier
bwmeta1.element.element-from-psjc-85e8c5d5-bb83-3e2c-8256-1a0713c7c480
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