Antigen receptor signaling is subverted by and immunomodulatory product secreted by a filarial nematode

• Authors: M.M. Harnett , W. Harnett
• Languages of publication: EN

Abstracts

EN

ES-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae which is able to inhibit antigen receptor-stimulated proliferation of B and T lymphocytes in vitro and in vivo. The active component of ES-62 appears to be PC as the results obtained with ES-62 are broadly mimicked by PC conjugated to bovine serum albumin or PC alone. Such desensitization of lymphocyte responsiveness appears to reflect an uncoupling of the antigen receptors from key intracellular proliferative signaling events, such as the phosphoinositide-3-kinase (PI-3K), protein kinase C (PKC) and Ras mitogen-activating protein kinase (RasMAPK) pathways. ES-62 mediates such immunomodulatory effects at concentrations equivalent to those found for PC-containing molecules in the bloodstream of parasitized humans and, thus, ES-62 provides a model system for dissecting the mechanisms of immune evasion induced by related PC-containing glycoproteins expressed by human filarial nematodes.

Keywords

EN

IMMUNE EVASION; LYMPHOCYTE; NEMATODA; NEMATODE; PHOSPHORYLCHOLINE; SIGNAL TRANSDUCTION

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 4
• Pages: 263-270

Contributors

author

M.M. Harnett

author

W. Harnett

• Document Type: REVIEW
• Publication order reference: M.M. Harnet, Departments of Immunology, University of Glasgow, Glasgow G11 6NT, UK