Lidocaine inhibits neurite growth in mouse dorsal root ganglion cells in culture

• Authors: H. Hiruma , H. Maruyama , Z.B. Simada , T. Katakura , S. Hoka , T. Takenaka , T. Kawakami
• Languages of publication: EN

Abstracts

EN

Recent clinical and experimental studies suggest the effectiveness of lidocaine in blocking neuropathic pain. Because it has been demonstrated that the pathogenetic mechanisms of neuropathic pain involve morphological changes in afferent neuronal terminals onto spinal cord, we examined the effects of lidocaine on neurite growth in isolated mouse dorsal root ganglion cells in culture. Incubation for 2-42 h with various concentrations of lidocaine (0.006 mM, 0.6 mM, and 30 mM) reduced the number of cells exhibiting neurites. The effects were time- and dose-dependent. Lidocaine therefore may exert its pharmacological effect, at least in part, by changing neuronal structures derived from sensory neurons.

Keywords

EN

DORSAL ROOT GANGLION; LIDOCAINE; MOUSE; NEURITE; NEUROPATHIC PAIN

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1999
• Volume: 59
• Issue: 4
• Pages: 323-327

Contributors

author

H. Hiruma

author

H. Maruyama

author

Z.B. Simada

author

T. Katakura

author

S. Hoka

author

T. Takenaka

author

T. Kawakami

• Document Type: article
• Publication order reference: H. Hiruma, Department of Physiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Email: [e-mail]