PL EN


Preferences help
enabled [disable] Abstract
Number of results
2005 | 53 | 4 | 283-296
Article title

Human T cell leukemia virus type 1: the role of Tax in leukemogenesis

Content
Title variants
Languages of publication
EN
Abstracts
EN
Human T cell leukemia virus type 1 (HTLV-1) is a complex human retrovirus which is the causative agent of adult T cell leukemia (ATL). ATL occurs in about 4% of carriers and develops after a long latent period. Although the precise mechanism of HTLV-1 oncogenesis remains unclear, the pathogenesis has been linked to the pleiotropic activity of the viral transcriptional activator protein Tax. Tax has been shown to regulate viral and cellular gene expression and to functionally interfere with proteins involved in cell-cycle progression and DNA repair. This review will focus on the role of Tax in p53 inhibition.
Keywords
References
Document Type
REVIEW
Publication order reference
Cynthia A. Pise-Masison, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
YADDA identifier
bwmeta1.element.element-from-psjc-83806986-4c1f-36f3-a63e-77dcc6593dfc
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.