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2005 | 53 | 2 | 115-126
Article title

IL-15 and IL-15Ra in CD4+T cell immunity

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Languages of publication
EN
Abstracts
EN
The cytokine IL-15 performs numerous functions, such as promotion of growth and survival, on a plethora of cell types from both the lymphoid and non-lymphoid compartments. Therefore, mice genetically engineered to either lack or overexpress functional IL-15 display reduced immunological responses and leukemia, respectively. Surprisingly, IL-15 protein is hardly found in serum or body fluids. Due to the lack of a clear demonstration of its presence as protein, IL-15 was often referred to as a 'ghost cytokine'. Recently, however, membrane-bound IL-15 was detected in both a membrane-anchored form and an IL-15Ralpha-bound form on monocytes. Interestingly, the latter complex can be transpresented to cells expressing the intermediate-affinity IL-2/15Rbeta- gammaC receptor and thereby support the survival and proliferation of T cells. Moreover, overlapping promoter elements indicate a model of co-regulation of IL-15 and IL-15Ralpha by which IL-15 activities are controlled in a cell-contact-dependent manner. In this review, recent reports on IL-15 are combined with previous observations and discussed in terms of their functional consequences for CD4+ T cell responses.
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Year
Volume
53
Issue
2
Pages
115-126
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
Tom Van Belle, Molecular Immunology Unit, Department for Molecular Biomedical Research, VIB, University Ghent, Technologiepark 927, 9052 Gent-Zwijnaarde, Belgium
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-82635989-1931-3ae4-8d33-c49cb299df10
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