Cytokine-producing T cell subsets in human leishmaniasis

• Authors: K. Kemp
• Languages of publication: EN

Abstracts

EN

Leishmania specific Th1/Th2 cells have been identified in humans as well as in mice. There is a correlation between the clinical outcome of the infection and the cytokine response profile. Generally, the production of Th2 cytokines leads to severe infection, whereas the production of Th1 cytokines leads to subclinical or mild infections. In mice, an infection leads to a polarisation of either Th1 or Th2 Leishmania antigen specific cells. In contrast, both Th1 and Th2 Leishmania antigen specific cells can be identified in humans cured from L. donovani infections. Theoretically, Th1 cells and Th2 cells mutually down-regulate each other. However, the presence of antigen specific regulatory T cell subsets may provide an environment that allows the presence of both Th1 and Th2 cells.

Keywords

EN

CYTOKINE; HUMAN; LEISHMANIASIS; T CELL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 3
• Pages: 173-176

Contributors

author

K. Kemp

• Document Type: REVIEW
• Publication order reference: K. Kemp, Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet) Copenhagen, Denmark