Chromosomal mosaicism on amniotic interphase nuclei detected by multiprobe FISH

• Authors: M. Constantinou , E. Zajac , B. Kaluzewski
• Languages of publication: EN

Abstracts

EN

So far classical prenatal detection of chromosome aberrations has been limited to the evaluation of metaphase by means of time-consuming cytogenetic techniques. The MultiVision PGT test enables a simultaneous detection of aneuploidies of chromosomes 13 ,18, 21, X, and Y, even 24 h after amniocentesis. In the presented case, this test detected prenatally a chromosomal mosaicism 69,XYY[35]/46,XY[65]. This result was not confirmed after birth, by the same test on blood smear. The discrepancy is difficult to explain.

Keywords

EN

AMNIOCYTE; MOSAICISM; POLYPLOIDY

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 2003
• Volume: 44
• Issue: 4
• Pages: 557-559

Contributors

author

M. Constantinou

author

E. Zajac

author

B. Kaluzewski

• Document Type: SHORT REPORT
• Publication order reference: M. Constantinou, Department of Medical Genetics, Medical University of Lodz, ul. Sterling 1/3, 91-425 Lodz, Poland