Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results
2002 | 56 | 5 | 589-602

Article title

Fatty acids as a potential adjuvant in cancer therapy

Title variants

Languages of publication



This review presents pro- and anticancer effects of fatty acids in vitro and in vivo. The epidemiological and experimental data indicate that short-chain saturated and long-chain unsaturated omega-3 fatty acids exert protective effects against some cancers. In the contrary, omega-6 fatty acids are rather procancerous and can increase tumour proliferation. The possible mechanisms are still not fully understood and are very variable including: suppression of neoplastic transformation, direct cytotoxicity, apoptosis induction, antiangiogenicity etc. Experimental data indicate that fatty acid composition of cancer cells in cultures or in animals can be modified to make the cells more susceptible to lipid peroxidation, increasing the cell damage due to oxidant stress and make the cells more sensitive to chemotherapy. It is reasonable to suppose that fatty acids supplementation can make an enrichment of traditional tools for modern anticancer strategies.




Document Type


Publication order reference

W. Przybyszewski, Centrum Onkologii-Instytut im.M.Sklodowskiej-Curie, Wybrzeze Armii Krajowej 15, 44-101 Gliwice, Poland


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.