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2003 | 44 | 1 | 111-113
Article title

Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida

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Languages of publication
EN
Abstracts
EN
We analyzed the role of the C677T polymorphism of the 5,10-methylenetetrahydrofolate and the A66G polymorphism of the methionine synthase reductase genes as risk factors for occurrence of spina bifida. The studied population included 106 mothers and 104 children from affected families, and a control group of 100 adults. We found statistically significant differences between the occurrence of the homozygosity in these polymorphisms in the groups of mothers and children with thoracolumbal defects (C677T polymorphism) and lumbosacral defects (A66G polymorphism). We postulate that these polymorphisms should be regarded as independent risk factors for spina bifida.
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Publisher

Year
Volume
44
Issue
1
Pages
111-113
Physical description
Contributors
References
Document Type
SHORT COMMUNICA
Publication order reference
M. Bik-Multanowski, Chair and Department of Pediatrics, Polish-American Children?s Hospital, Jagiellonian University, ul. Wielicka 265, 30-663 Krakow, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-7db5a6f6-d030-35ac-be03-4a194b6856a6
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