PL EN


Preferences help
enabled [disable] Abstract
Number of results
2007 | 55 | 4 | 205-217
Article title

Tumor resistance to CD8+ T cell-based therapeutic vaccination

Authors
Title variants
Languages of publication
EN
Abstracts
EN
CD8+ cytotoxic T lymphocytes (CTLs) play an important role in antitumor immunity. Induction of tumor-specific CTLs is one major strategy for tumor immunotherapy. However, therapeutic vaccinations used to treat firmly established tumors are generally ineffective. A thorough understanding of the mechanisms underlying tumor resistance to CTL-based therapeutic vaccination is very important in the tumor immunology field. There are two main mechanisms by which tumors develop resistance to CTL-based therapeutic vaccinations. One is that tumors induce peripheral tolerance of tumor-specific CD8+ T cells. The other is that tumor cells themselves develop immune evasion mechanisms to prevent recognition and killing by CTLs. This review focuses on recently reported cellular and molecular mechanisms of CD8+ T cell tolerance and immune evasion in tumors and discusses about the possibilities to improve tumor immunotherapy.
Keywords
Publisher

Year
Volume
55
Issue
4
Pages
205-217
Physical description
Contributors
author
author
author
References
Document Type
REVIEW
Publication order reference
Liang Qiao, Division of Developmental Immunology, The La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-7d2bb23f-c1b5-3d6f-b189-67e1ba1965cb
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.