Role of hypercapnia in brain oxygenation in sleep-disordered breathing

• Authors: A. Brzecka
• Languages of publication: EN

Abstracts

EN

Adaptive mechanisms may diminish the detrimental effects of recurrent nocturnal hypoxia in obstructive sleep apnea (OSA). The potential role of elevated carbon dioxide (CO2) in improving brain oxygenation in the patients with severe OSA syndrome is discussed. CO2 increases oxygen uptake by its influence on the regulation of alveolar ventilation and ventilation-perfusion matching, facilitates oxygen delivery to the tissues by changing the affinity of oxygen to hemoglobin, and increases cerebral blood flow by effects on arterial blood pressure and on cerebral vessels. Recent clinical studies show improved brain oxygenation when hypoxia is combined with hypercapnia. Anti-inflammatory and protective against organ injury properties of CO2 may also have therapeutic importance. These biological effects of hypercapnia may improve brain oxygenation under hypoxic conditions. This may be especially important in patients with severe OSA syndrome.

Keywords

EN

ADAPTATION; CEREBRAL BLOOD FLOW; HYPERCAPNIA; HYPOXIA; NEUROPROTECTION; SLEEP APNEA

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2007
• Volume: 67
• Issue: 2
• Pages: 197-206

Contributors

author

A. Brzecka

• Document Type: REVIEW
• Publication order reference: A. Brzecka, Department of Pulmonology and Lung Cancer, Wroclaw Medical University, Grabiszynska 105, 53-439 Wroclaw, Poland