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Journal
2010 | 3 | 146-172
Article title

Chemically modified siRNA duplexes

Authors
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Languages of publication
EN
Abstracts
EN
RNA interference (RNAi) is a powerful biological process for a sequence-specific silencing of a gene expression in diverse eukaryotic cells. Discovery of this phenomena had tremendous significance for functional genomics and development of novel gene-specific therapies. The future success of RNAi technology relies on identifying appropriate chemical modifications to improve stability, potency and in vivo cellular delivery of the effector moieties, siRNAs. The presented review attempts to describe some of the biological challenges associated with using synthetic siRNAs to effect RNAi and summarizes the role of the chemical tools in the application of RNAi technology.
Journal
Year
Issue
3
Pages
146-172
Physical description
Contributors
author
References
Document Type
REVIEW
Publication order reference
Malgorzata Sierant, Centrum Badan Molekularnych i Makromolekularnych, Polska Akademia Nauk, ul. Sienkiewicza 112, Lodz, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-7a7b863f-70fa-3240-9370-72605f03c002
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