Chemically modified siRNA duplexes
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RNA interference (RNAi) is a powerful biological process for a sequence-specific silencing of a gene expression in diverse eukaryotic cells. Discovery of this phenomena had tremendous significance for functional genomics and development of novel gene-specific therapies. The future success of RNAi technology relies on identifying appropriate chemical modifications to improve stability, potency and in vivo cellular delivery of the effector moieties, siRNAs. The presented review attempts to describe some of the biological challenges associated with using synthetic siRNAs to effect RNAi and summarizes the role of the chemical tools in the application of RNAi technology.
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Malgorzata Sierant, Centrum Badan Molekularnych i Makromolekularnych, Polska Akademia Nauk, ul. Sienkiewicza 112, Lodz, Poland