Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results
2007 | 55 | 2 | 127-130

Article title

Do Langerhans cells play a role in vulvar epithelium resistance to squamous cell carcinoma?

Title variants

Languages of publication

EN

Abstracts

EN
Introduction: Langerhans cells (LCs) are a very important part of the skin immune system. Materials and Methods: Skin biopsies taken from 13 women after the removal of vulvar squamous cell carcinoma (SCC) who had not been treated earlier for any vulvar diseases were investigated. The control group consisted of 12 women who underwent a plastic surgical operation of the vulva region. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded tissues samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra). Results: This study showed a large decrease in LCs in vulvar SCC. Conclusions: It is postulated that the reduction in the number of LCs may be one of the reasons for a higher tendency of carcinogenesis in the vulvar region. Their role as a main element of the skin immune system in the initiation of this process needs further investigation. It is possible that research on LCs in the skin will cast a new light on their role and even contribute to the prophylaxis and treatment of skin and mucosa carcinomas.

Contributors

References

Document Type

ARTICLE

Publication order reference

Helena Rotsztejn, Section of Dermatology, Research Institute of the Polish Mother?s Memorial Hospital, Rzgowska 281/284, 93-338 Lodz, Poland

Identifiers

YADDA identifier

bwmeta1.element.element-from-psjc-7a696fdc-bff9-3682-a9dd-07b34c08eee5
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.