PL EN


Preferences help
enabled [disable] Abstract
Number of results
2002 | 62 | 3 | 131-139
Article title

Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. II. Astrocytic and macrophage reaction toward the axonal destruction

Content
Title variants
Languages of publication
EN
Abstracts
EN
We report here the microglial (macrophage) and astrocytic reaction in several models of transmissible spongiform encephalopathies (TSEs) or prion diseases. With the low power electron microscopy it was readily apparent that myelinated vacuoles were surrounded by cells and their processes. The latter belonged either to hyperplastic reactive astrocytes or to macrophages. Typically reactive astrocytes exhibited cytoplasm filled with innumerable glial filaments and, occasionally, other organelles (like cilia) and abundant tortuous intercellular junctions of adhesive plaque junction type. Desmosome-like junctions connecting astrocytic elements were also seen. As described earlier, astrocytic processes were occasionally interdigitated with oligodendroglial cells and their processes. Two types of macrophages were readily described. The majority of them exhibited electron-dense cytoplasm and numerous ?empty? vacuoles (digestive chambers) containing cellular debris. Occasional vacuoles were surrounded by a thin collar reminiscent of ?lyre-like inclusions? of the second type of macrophages. The latter were rare and characterized by numerous ?lyre-like? inclusions. Several mylinated fibres were clearly engulfed by the cytoplasm of a macrophage containing unusual annulate lamellae.
References
Document Type
ARTICLE
Publication order reference
P. P. Liberski, Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-7960f768-0e2e-3a3a-83e9-350644c962a7
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.